Project code: PN-III-P4-ID-PCE-2020-2375
Contract No: PCE 208
Breast implants silicon outshell bioinstructive engineering for preventing microbial and fibrosis development
Breast cancer is a significant public health issue for women and it is currently targeted by the national strategies for health outcomes. Considering both physical and psychological impacts on health-related quality of life, a large percentage of women with a mastectomy will choose breast reconstruction by implants. One inevitable consequence of silicone breast implantation and foreign body response is the capsular contracture, which often leads to health complications, need for revision surgery.
Team
We are a young and energetic team of enthusiastic professionals who believe in innovative strategies and out-of-the-box solutions.
Abstract
Results
The results obtained within the project have been utilized and disseminated nationally and internationally through articles (4 published, 2 submitted for evaluation in ISI journals), patents (3), invited presentations (3), oral presentations (4), posters, as well as participation in International Invention Salons (4 international awards: 1 gold medal Euroinvent, 2 gold medals PROINVENT, and Best Student Award at the EMRS conference in France for Dr. A. Bonciu). All reported results from funded activities mentioned the funder's name and the contract number.
The project's website has been continuously developed and updated in both English and Romanian versions (https://ancabonciuub.wixsite.com/breaslife/).
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The approached innovative bioengineering solutions for achieving this objective refers to:
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Multi-architectural 2 and the 3-dimensional surface texturing of silicone for reducing the wear and friction of implant biointerfaces surface, inhibiting bacteria and fibrosis.
Surface chemistry by using the synergetic effect of zwitterionic polymers, antifibrotic and anti-inflammatory compounds.
Surface multiple specific functionalizations by laser techniques for the embedding of bioactive synergetic compoundsin a biodegradable polymer coating.